ALCAZAR VACA, Manuel Jesus,ANDRES GIL, Jose Ignacio,LETAVIC, Michael A.,RUDOLPH, Dale A.,SHIREMAN, Brock T.,STENNE, Brice M.,ZIFF, Jeannie M.
申请号：
ES14722874
公开号：
ES2654288T3
申请日:
2014.03.14
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of formula (I): ** Formula ** in which: each R2 is independently selected from the group consisting of halo, CN, C1-C3 alkyl, perhaloalkyl, C1-C3 alkoxy and perhaloalkoxy； n is an integer from 0-3； X is independently selected from the group consisting of H, C1-C3 alkyl, C3 cycloalkyl, perfluoroalkyl, -NH2, and -N (CH3) 2； Y and Z are independently H or CH3； R1 is independently selected from the group consisting of: ** Formula ** Re and Rf are H or C1-C3 alkyl； Rg is H, F, or perfluoroalkyl； Rh is H, C1-3 alkyl, -CH2CH2OCH3 or perfluoroalkyl； and R1 is H or halogen； Pharmaceutically acceptable salts of compounds of Formula (I).Un compuesto de fórmula (I):**Fórmula** en la que: cada R2 se selecciona independientemente del grupo que consiste en halo, CN, alquilo C1-C3, perhaloalquilo, alcoxi C1-C3 y perhaloalcoxi； n es un número entero de 0-3； X se selecciona independientemente del grupo que consiste de H, alquilo C1-C3, cicloalquilo C3, perfluoroalquilo, -NH2, y -N (CH3)2； Y y Z son independientemente H o CH3； R1 se selecciona independientemente del grupo que consiste en:**Fórmula** Re y Rf son H o alquilo C1-C3； Rg es H, F, o perfluoroalquilo； Rh es H, alquilo C1-3, -CH2CH2OCH3 o perfluoroalquilo； y R1 es H o halógeno； sales farmacéuticamente aceptables de compuestos de Fórmula (I).
