MALONE, Thomas C.,HULL, Clarence,BORAL, Sougato,WURSTER, Julie A.,EDELMAN, Jeffrey L.,ROBINSON, Michael R.
申请号：
ES12810524
公开号：
ES2623652T3
申请日:
2012.12.27
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formula I: ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: X1 is N and X2 is S； L1 is selected from the group consisting of -N (R) -, -N (R) -C (>； = O) -N (R) -, -OC (>； = O) -N (R) -, -N (R) -C (>； = O) - and -C (>； = O) -N (R) -； L2 is selected from the group consisting of a covalent bond, -N (R) -, -N (R) -C (>； = O) -, -C (>； = O) -N (R) - and -N ( R) -C (>； = O) - N (R) -； each R is independently H or C1-6 alkyl； each R1 is independently selected from the group consisting of alkyl, C1-6 haloalkyl, halogen and OR； or wherein two adjacent R1 groups taken together with the carbon atoms to which they are attached form a six membered aryl or a five or six membered heteroaryl； n is 0, 1 or 2； R2 is selected from the group consisting of: a) H； b) C1-6 alkyl unsubstituted or substituted with one or two substituents selected from the group consisting of heterocyclyl, -C (>； = O) OR, hydroxy, C1-6 alkoxy and aryl； and c) ** Formula ** and R3 is selected from the group consisting of H, hydroxy, -NO2, aryl and heteroaryl, wherein said aryl or heteroaryl is unsubstituted or substituted with one to three substituents selected from the group consisting of halo, C1-6 haloalkyl and C1-6 alkyl.Un compuesto de fórmula I:**Fórmula** o una sal farmacéuticamente aceptable del mismo, en donde: X1 es N y X2 es S； L1 se selecciona del grupo que consiste en -N(R)-, -N(R)-C(>；=O)-N(R)-, -O-C(>；=O)-N(R)-, -N(R)-C(>；=O)- y -C(>；=O)-N(R)- ； L2 se selecciona del grupo que consiste en un enlace covalente, -N(R)-, -N(R)-C(>；=O)-, -C(>；=O)-N(R)- y -N(R)-C(>；=O)- N(R)-； cada R es independientemente H o alquilo C1-6； cada R1 se selecciona independientemente del grupo que consiste en alquilo, haloalquilo C1-6, halógeno y OR； o en donde dos grupos R1 adyacentes tomados junto con los átomos de carbono a los que están unidos forman un arilo de seis miembros o un heteroarilo de cinco o seis miembros； n es 0, 1 o 2； R2 se selecciona del
