PROBLEM TO BE SOLVED: To provide an agent for preventing/ameliorating retinopathy exhibiting superior prevention/amelioration effect on retinopathy such as diabetic retinopathy.SOLUTION: Cryptoxanthin is a kind of carotenoids. Cryptoxanthin and/or an ester thereof exhibits superior retinopathy prevention/amelioration effect and can be used as an active ingredient of an agent for preventing or ameliorating retinopathy.