CHRISTOPH STEENECK,CHRISTIAN GEGE,OLAF KINZEL,GERALD KLEYMANN,THOMAS HOFFMANN,STEVEN GOLDBERG,ANNE M. FOURIE,XIAOHUA XUE,HARIHARAN VENKATESAN,VIRGINIA TANIS
申请号：
PT15802227
公开号：
PT3212643T
申请日:
2015.10.30
申请国别(地区):
PT
年份:
2019
代理人:
摘要：
The present invention comprises compounds of Formula I. wherein: X, A 1 , A 2 , A 3 , A 4 , R 1 , R 2 , and R 3 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORyt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.
