Avigdor Shafferman,Anat Zvi,John Fulkerson,Jerald C. Sadoff
申请号：
US12863040
公开号：
US08728492B2
申请日:
2009.01.12
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Malaria vaccines based on polyepitope constructs that elicit cell-mediated immunity against a broad spectrum of malaria parasites and which cover the majority of HLA alleles are provided. Epitopes in the polyepitope constructs are from regions of the Plasmodium falciparum circumsporozoite protein (CSP) known to contain CD4 and CD8 T cell epitopes, and include both epitopes from highly variable and highly conserved regions of CSP.
