The United States of America; as represented by the Secretary of the Army
发明人:
Sheetij Dutta
申请号：
US14798975
公开号：
US09919040B2
申请日:
2015.07.14
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides novel nucleotide sequence and other constructs used for expression of novel recombinant P. falciparum circumsporozoite proteins in bacterial cells such as E. coli. Processes are provided for producing a soluble recombinant P. falciparum CSP from E. coli. Methods to produce a human-grade, highly immunogenic anti-malaria vaccine based on CSP are shown. The novel recombinant P. falciparum circumsporozoite protein by itself or in combination with other malaria antigens or adjuvants can form the basis of an effective malaria vaccine.
