Lakmal Jayasinghe;James Anthony Clarke;John Milton;Ruth Moysey;James White;Luke McNeill
发明人:
Lakmal Jayasinghe,John Milton,Luke McNeill,James Anthony Clarke,James White,Ruth Moysey
申请号：
US13147176
公开号：
US09222082B2
申请日:
2010.01.29
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention provides method of covalently coupling two or more moieties, the method comprising: (a) providing a first moiety having covalently attached thereto (i) at least one first linker comprising a first hybridizable region and (ii) at least one first group capable of forming a covalent bond； (b) providing a second moiety having covalently attached thereto (i) at least one second linker comprising a second hybridizable region capable of hybridizing to the first hybridizable region and (ii) at least a second group capable of forming a covalent bond with the first group； (c) contacting the first and second moieties under conditions that allow the first and second hybridizable regions to hybridize and link the moieties； and (d) exposing the linked moieties to conditions that allow the formation of a covalent bond between the first and second groups.
