The present disclosure relates to N-(substituted naphthyl-ethyl) substituted guanamine compounds and their use as melatonin receptor agonists and 5-HT 2c receptor antagonists, in particular to compounds of formula I or pharmaceutically acceptable thereof Accepted salts, solvates, or mixtures thereof, and pharmaceutical compositions thereof, wherein X, R 1 , R 2 are as defined herein.本公開涉及N-(取代萘基-乙基)取代醯胺類化合物及其作為褪黑素受體激動劑及5-HT2c受體拮抗劑的用途，具體涉及式I化合物或其藥學上可接受的鹽、溶劑合物或者它們的混合物及其藥用組合物，其中X、R1、R2如本文中所定義。
