A compound of Formula (I) or a pharmaceutically acceptable salt or isomer thereof, for use in the treatment of nervous system disorders, wherein Formula (I) is: wherein R is independently selected from hydrogen or R1R2R3, wherein R1 is C1-10 alkyl； R2 is aryl and R3 is selected from hydrogen, OH, C(O)NH2, linear or branched C1-C10 alkyl or C3-C8 cycloalkyl, is provided. The nervous system disorder may be selected from epilepsy, ischemia, stroke, traumatic brain injury, hypoxia, Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, multiple sclerosis, dementia, schizophrenia, sleep disorders including insomnia. A compound of formula (I) or pharmaceutically acceptable salt or isomer thereof, for use in the treatment of pain is provided. The pain is selected from neuropathic, peripheral acute and chronic, somatic, visceral, neuroma, diabetic neuropathy, surgical pain, chemotherapy-induced pain, bone pain, inflammatory, phantom limb, myalgia and multiple sclerosis-related pain. The bone pain may be fracture or cancer pain. A pharmaceutical composition comprising said compounds and a pharmaceutically or therapeutically acceptable excipient or carrier is provided. The compounds are selective A1 adenosine receptor agonists.
