Luis Enrique Fernández Molina,Belinda Sánchez Ramírez,Audry Fernández Gómez,Gretchen Bergado Báez,Circe Mesa Pardillo,Lisset Chao García,Narjara González Suárez,Dayana Pérez Martínez,Diana Rosa Hernán
申请号：
US16760954
公开号：
US20200268878A1
申请日:
2018.10.24
申请国别(地区):
US
年份:
2020
代理人:
摘要：
This invention describes ways of obtaining nano-particulated adjuvants formed by different synthetic variants of GM3 ganglioside. Depending on the fine structure of the fatty acid in the ceramide of the synthetic GM3, said adjuvants are able to stimulate specifically and in a specialized way the humoral or cellular immune response against accompanying antigens. Particularly, this invention provides immunogenic vaccine compositions that comprise peptides, polypeptides or proteins and the aforementioned nanoparticles, which are formed through the dispersion of hydrophobic proteins of the outer membrane complex (OMC) of Neisseria meningitidis in solutions containing fully synthetic variants of the GM3 ganglioside.
