THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMT OF HEALTH AND HUMAN SERVICES;BAYLOR COLLEGE OF MEDICINE;THE UNITED STATES OF AMERICA; AS REPRESENTED BY THE SECRETARY; DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
PURI, ANU,BLUMENTHAL, ROBERT P.,JOSHI, AMIT,TATA, DARAYASH B.,VIARD, MATHIAS
申请号：
CA2917545
公开号：
CA2917545A1
申请日:
2014.07.09
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Embodiments of photoactivatable, lipid-based nanoparticles are disclosed, as well as methods of making and using the nanoparticles. Pharmaceutical compositions including the nanoparticles also are disclosed. The lipid-based nanoparticles include a vesicle wall surrounding a cavity, wherein the vesicle wall includes (i) a lipid bilayer comprising 1,2-bis(tricosa- 10,12- diynoyl)-sn-glycero-3-phosphocholine (DC8,9PC), dipalmitoylphosphatidylcholine (DPPC), and (ii) 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a (HPPH) within the lipid bilayer. The nanoparticles may further include an agent within the cavity.
