An object of the present invention is to provide an agent for sedating the response of skin to external stimulation. The aforementioned object was achieved by finding a component that promotes CD39 gene expression in Langerhans cells. More specifically, the present invention is based on the finding that the combination of carboxymethyl-beta glucan or a salt thereof, polyoxyethylene (POE) /polyoxypropylene (POP) random copolymer dimethyl ether and rosewater promotes CD39 gene expression.本發明之目標係提供用於緩和皮膚對外在刺激之反應之製劑。該上述目標係藉由發現促進朗格漢斯細胞(Langerhans cell)中之CD39基因表現之組份來達成。更特定而言,本發明係基於羧甲基-β葡聚糖或其鹽、聚氧乙烯(POE)/聚氧丙烯(POP)無規共聚物甲醚及玫瑰水之組合促進CD39基因表現之發現。
