TOMAS GUCKY,Eva REZNICKOVA,Radek JORDA,Vladimir KRYSTOF,Miroslav STRNAD,Tereza RADOSOVA MUCHOVA,Vladimir DIVOKY
申请号：
US16494650
公开号：
US20200087306A1
申请日:
2018.03.19
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to novel 2,6-disubstituted-9-cyclopentyl-9H-purines of general formula I, capable of inhibiting the activity of kinases such as FLT3, CDKs and PDGFRs in cancer and other related proliferative diseases. The invention further includes pharmaceutical compositions containing the 2,6-disubstituted-9-cyclopentyl-9H-purines. Compounds of the present invention can be used as active ingredients of a pharmaceutical compositions for treating acute myeloid leukemia (AML).
