COMPOSITIONS COMPRENANT DES COMPOSES THIENOPYRIMIDINE ET THIENOPYRIDINE ET PROCEDES D'UTILISATION ASSOCIES

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专利权人:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人:

GREMBECKA, JOLANTA,CIERPICKI, TOMASZ,BORKIN, DMITRY,HESS, JAY,SUN, DUXIN,LI, XIAOQIN

申请号：

CA2904612

公开号：

CA2904612A1

申请日:

2014.03.10

申请国别(地区):

CA

年份:

2014

代理人:

摘要：

The present invention relates generally to thienopyrimidine and thienopyridine class compounds and methods of use thereof. In particular embodiments, the present invention provides compositions comprising thienopyrimidine and thienopyridine class compounds and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins (e.g., for the treatment of leukemia, solid cancers and other diseases dependent on activity of MLL1, MLL2, MLL fusion proteins, and/or menin).

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/