University Health Network;Hospital for Special Surgery
发明人:
Carl Blobel,Thorsten Maretzky,David McIlwain,Tak Wah Mak
申请号：
US14654139
公开号：
US10024844B2
申请日:
2013.12.20
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Disclosed are methods for treating a subject with an EGFR dependent pathology. The method comprises the step of administering to the subject an effective amount of an agent (“First Agent”) that decreases the biological activity of iRhom1 and an effective amount of an agent (“Second Agent”) that decreases the biological activity of iRhom2. Alternatively, the method comprises the step of administering to the subject an effective amount of an agent (“First Agent”) that modulates formation of a complex between iRhom 1 and TACE and an effective amount of an agent (“Second Agent”) that modulates formation of a complex between TACE and iRhom2. Also disclosed are assays for identifying such agents.
