VAZQUEZ, Manuel Perez,MORSHED, M. Monzur,HICKEY, Jennifer L.,KAFAL, Adam Paul,GILLARD, James,PATEL, Narendra,CHAKKA, Sai Kumar,ROUGHTON, Andrew L.,POUPART Marc-André,YANG, Gaoqiang
申请号：
EP16863253
公开号：
EP3387004A4
申请日:
2016.11.14
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
There is described herein antagonists of α4β7 integrin, and more particularly to cyclic peptide antagonists. Accordingly, there is described herein a compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are various substituents； stereocentres 1*, 2* and 3* are each independently selected from R and S； n is 1, 2, 3, or 4 and where n is 2-4, Z is an amino terminus of an amino acid； -C=0- adjacent L is the carboxy terminus of an amino acid； and L along with Z and -C=0- is a peptide.
