There is described herein antagonists of α4β7 integrin, and more particularly to cyclic peptide antagonists. Accordingly, there is described herein a compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are various substituents； stereocentres 1*, 2* and 3* are each independently selected from R and S； n is 1, 2, 3, or 4 and where n is 2-4, Z is an amino terminus of an amino acid； -C=0- adjacent L is the carboxy terminus of an amino acid； and L along with Z and -C=0- is a peptide.
