Process for the synthesis of 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one compounds, and application in the synthesis of ivabradine

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专利权人:

LES LABORATOIRES SERVIER

发明人:

ALEXANDRE LE FLOHIC

申请号：

NZ62291514

公开号：

NZ622915A

申请日:

2014.03.25

申请国别(地区):

NZ

年份:

2015

代理人:

摘要：

Disclosed is a process for the synthesis of a compound of formula I (a 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one) from the reduction of a 7,8-dimethoxy-benzazepine-2,4(3H,5H)-dione of formula VII. Also disclosed is the use of this process in the synthesis of ivabradine. Further disclosed are two intermediates from the synthesis, the compound of formula VIII 3-{ 3-[{ [(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl} (methyl)amino]-propyl} -7,8-dimethoxy-1H-3-benzazepine-2,4(3H,5H)-dione and also the compound of formula XIV { 2-[2-({ 3-[{ [(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl} (methyl)-amino]propyl} amino)-2-oxoethyl]-4,5-dimethoxyphenyl} acetic acid.

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