Process for the enzymatic synthesis of (7S)-1-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl) N-methyl methanamine, and application in the synthesis of ivabradine and salts thereof

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专利权人:

Les Laboratoires Servier

发明人:

PEDRAGOSA MOREAU, Sandrine,LEFOULON, Francois,MORIS VARAS, Francisco,GONZALEZ SABIN, Javier

申请号：

AU2013206562

公开号：

AU2013206562B2

申请日:

2013.06.27

申请国别(地区):

AU

年份:

2017

代理人:

摘要：

#$%^&*AU2013206562B220170202.pdf#####PROCESS FOR THE ENZYMATIC SYNTHESIS OF (7S)-1-(3,4DIMETHOXYBICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL) N-METHYL METHANAMINE, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND SALTS THEREOF Abstract A process for the enzymatic synthesis of the compound of formula (I), (7S)-1(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl) N-methyl methanamine: (I) (s>； and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.

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