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COMPOSIÇÃO FARMACÊUTICA CONTENDO CANDESARTAN CILEXETIL E AMLODIPINA
专利权人:
ADAMED PHARMA S.A.
发明人:
AGNIESZKA CIEPLUCHA
申请号:
PT13826632
公开号:
PT2934488T
申请日:
2013.12.19
申请国别(地区):
PT
年份:
2019
代理人:
摘要:
A combination pharmaceutical composition comprising candesartan cilexetil and amiodipine or a pharmaceutically acceptable salt thereof, a process for the preparation of such composition and unit dosage form comprising such a composition. The composition consists of a granulate containing candesartan cilexetil, polyethylene glycol and other excipients, wherein the weight ratio of candesartan cilexetil to polyethylene glycol is in the range from 5: 1 to 2: 1, and extragranular phase of powder blend comprising amiodipine or a pharmaceutically acceptable salt thereof and excipients. The composition is prepared by mixing the granulate prepared by wet granulation and extragranular phase.
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