A pharmaceutical composition containing candesartan cilexetil and amlodipine

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专利权人:

Adamed Sp. z o.o.

发明人:

Cieplucha, Agnieszka

申请号：

AU2013365715

公开号：

AU2013365715B2

申请日:

2013.12.19

申请国别(地区):

AU

年份:

2017

代理人:

摘要：

A combination pharmaceutical composition comprising candesartan cilexetil and amiodipine or a pharmaceutically acceptable salt thereof, a process for the preparation of such composition and unit dosage form comprising such a composition. The composition consists of a granulate containing candesartan cilexetil, polyethylene glycol and other excipients, wherein the weight ratio of candesartan cilexetil to polyethylene glycol is in the range from 5: 1 to 2: 1, and extragranular phase of powder blend comprising amiodipine or a pharmaceutically acceptable salt thereof and excipients. The composition is prepared by mixing the granulate prepared by wet granulation and extragranular phase.

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