COMPOSITIONS ET MÉTHODES PERMETTANT D'INHIBER L'EXPRESSION DU GÈNE DE HIF2ALPHA

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专利权人:

Arrowhead Pharmaceuticals; Inc.

发明人:

WONG, So,LEWIS, David, L.,ROZEMA, David, B.,WAKEFIELD, Darren, H.,CHEN, Weijun,ALMEIDA, Lauren, J.,BLOKHIN, Andrei, V.,CARLSON, Jeffrey, C.,NICHOLAS, Anthony, L.,ALMEIDA, Aaron,KANNER, Steven, B.,BENS

申请号：

EP16804086

公开号：

EP3302503A4

申请日:

2016.05.27

申请国别(地区):

EP

年份:

2019

代理人:

摘要：

RNA interference (RNAi) triggers and RNAi trigger conjugates for inhibiting the expression of Hif2α (EPAS1) gene are described. Pharmaceutical compositions comprising one or more Hif2α RNAi triggers optionally with one or more additional therapeutics are also described. Delivery of the described Hif2α RNAi triggers to tumor cells in vivo provides for inhibition of Hif2α gene expression and treatment of cancer.

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