2-METHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES农业专利-农业学术服务平台

发明人:: GIRIJAVALLABHAN, VINAY,吉拉贾沃伯翰维纳,吉拉賈沃伯翰維納,BOGEN, STEPHANE,柏根史蒂芬,柏根史蒂芬,TRUONG, QUANG T.,楚昂邝T,楚昂鄺T,CHEN, PING,陈平,陳平,KEREKES, ANGELA,克拉克斯安琪拉,克拉克斯安琪拉,BENNETT, FRANK,伯纳特法兰克,伯納特法蘭克,ESPOSITE, SARA,伊

摘要：: The present invention relates to 2-Methyl Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, R1, R2 and R3, are as defined herein. The present invention also relates to compositions comprising at least one 2-Methyl Substituted Nucleoside Derivative, and methods of using the 2-Methyl Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.本發明係關於式(I)之2-甲基經取代之核苷衍生物,及其醫藥上可接受之鹽,其中B、R1、R2及R3係如本文所定義。本發明亦係關於包含至少一種2-甲基經取代之核苷衍生物之組合物,及使用該等2-甲基經取代之核苷衍生物用於治療或預防患者之HCV感染之方法。