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TREATMENT OF DISEASES ASSOCIATED WITH DISSEMINATING PROTEIN 2 (UCP2) BY INHIBITING A NATURAL ANTISENSE TRANSCRIPT TO UCP2
专利权人:
ИНК. (US);КУРНА
发明人:
КОЛЛАРД Джозеф (US),ХОРКОВА ШЕРМАН Ольга (US)
申请号:
RU2012121100/10
公开号:
RU2012121100A
申请日:
2010.12.23
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method of modulating the function and / or expression of a release protein 2 polynucleotide (UCP2) in a patient’s cells or tissues in vivo or vitro, comprising: contacting said cells or tissues with at least one antisense oligonucleotide ranging in length from 5 to 30 nucleotides, wherein said at least one oligonucleotide has a sequence that is at least 50% identical to the sequence inversely complementary to a polynucleotide containing 5 to 30 consecutive nucleotides within nucleotides 1-243 pos SEQ ID NO: 2 or nucleotides 1-802, the sequence of SEQ ID NO: 3, thereby modulating the function and / or expression of said uncoupling protein 2 polynucleotide (UCP2) in a patient’s cells or tissues in vivo or in vitro. 2. A method for modulating the function and / or expression of a release protein 2 polynucleotide (UCP2) in a patient’s cells or tissues in vivo or in vitro, comprising: contacting said cells or tissues with at least one antisense oligonucleotide of 5-30 nucleotides in length, moreover, the specified at least one oligonucleotide has a sequence of at least 50% identical to the sequence, figuratively complementary to the natural antisense sequence of polynucleotide uncoupling protein 2 (UCP2), with modulation therefore, the functions and / or expression of said uncoupling protein 2 polynucleotide (UCP2) in cells or tissues of a patient in vivo or in vitro. 3. A method for modulating the function and / or expression of a release protein 2 polynucleotide (UCP2) in a patient’s cells or tissues in vivo or in vitro, comprising: bringing said cells or tissue�1. Способ модулирования функции и/или экспрессии полинуклеотида разобщающего белка 2 (UCP2) в клетках или тканях пациента in vivo или vitro, включающий:приведение указанных клеток или тканей в контакт по меньшей мере с одним антисмысловым олигонуклеотидом, составляющим в длину от 5 до 30 нуклеотидов, причем указанный по меньшей мере один олигонуклеотид имеет последовательность, по меньшей мере на 50% идент
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http://www.ckcest.cn/home/
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