Berger, Dr. Markus,Frenzel, Dr. Thomas,Hilger, Dr. Christoph-Stephan,Jost. Dr. Gregor,Lohrke, Dra. Jessica,Panknin, Dr. Olaf,Pietsch, Hubertus,Platzek, Dr. Johannes,Sülzle, Dr. Detlev
申请号：
CU20170155
公开号：
CU20170155A7
申请日:
2016.05.30
申请国别(地区):
CU
年份:
2018
代理人:
摘要：
<；p>； The present invention relates to extracellular extracellular gadolinium chelate compounds of high relaxivity based on low molecular weight central polyamines, methods for preparing said compounds, and intermediates for preparing them. Such compounds are magnetic resonance imaging (MRI) contrast agents. <；/p>； <；p>； Gadolinium chelate compounds have the general formula (I), <；/p>； <；p>； FORMULA SPACE <；/ p >； <；p>； in which: <；/p>； <；p>； A represents a group <；/p>； <；p>； SPACE FOR FORMULA 2 (formula A) <；/p>；<；p>； in which group * indicates the junction point of said group with R1； R1 represents a group R3； <；/p>； <；p>； n represents an integer of 4； R2 represents a hydrogen atom； R3 represents a group selected from: <；/p>； <；p>； SPACE FOR FORMULA 3 <；/p>； <；p>； and <；/p>； <；p>； SPACE FOR FORMULA 4 (formulas B and C) <；/p>； <；p>； in which the groups * indicate the point of union of said group with the rest of the molecule； <；/p>； <；p>； R4 represents a hydrogen atom； R5 represents a hydrogen atom or a methyl group； or a stereoisomer, a tautomer, a hydrate or a solvate thereof,Or a mixture of lt, / P gt；<；p>；La presente invención se refiere a compuestos de quelatos de gadolinio extracelular extracelulares de alta relaxividad basadod en poliaminas centrales de bajo peso molecular, métodos para preparar dichos compuestos, y compuestos intermediarios para la preparación de los mismos. Dichos compuestos son agentes de contraste de imágenes de resonancia magnética (IRM).<；/p>； <；p>；Los compuestos de quelatos de gadolinio posee la fórmula general (I),<；/p>； <；p>；ESPACIO PARA LA FÓRMULA<；/p>； <；p>；en el cual:<；/p>； <；p>；A representa un grupo<；/p>； <；p>；ESPACIO PARA FÓRMULA 2 (fórmula A)<；/p>； <；p>；en que grupo * indica el punto de unión de dicho grupo con R1； R1 representa un grupo R3；<；/p>； <；p>；n representa u
