Academisch Ziekenhuis bij de Universiteit van Amsterdam
发明人:
申请号：
EP10714113.7
公开号：
EP2421954B1
申请日:
2010.04.21
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The present invention concerns human hepatocyte cell line cultures and their use in bioartificial liver (BAL) systems. These systems are used to treat subjects suffering from liver failure to temporarily compensate for loss of hepatocellular function and generally comprise a bioreactor loaded with functional liver cells. Until now, it has been problematic to acquire cells with a broad spectrum metabolic functionality, resembling that of freshly isolated human hepatocytes, to the extent that they are in fact suitable for successful clinical BAL application The present inventors have managed to develop human hepatocyte cell line cultures that display broad-spectrum metabolic functionality such as to render them particularly suitable for effective clinical BAL application.
