Sialic acid (α- (2 → 6))-D-pyranose derivatives and their synthesis and application

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专利权人:

北京大学

发明人:

葉 新山,楊 帆,鄭 秀静

申请号：

JP2013512727

公开号：

JP5815687B2

申请日:

2011.04.08

申请国别(地区):

JP

年份:

2015

代理人:

摘要：

N-acyl modified sialic acid (±-(2†’6))-D-aminopyranose derivatives, their synthesis methods and uses are disclosed. Sialic acid (±-(2†’6))-D-aminopyranose derivatives represented by formula 1 are synthesized by using D-aminogalactose (glucose) and sialic acid as raw materials, which are coupled with carrier proteins or polypeptides to obtain glycoprotein (glycopeptide) conjugates. Acetyl is replaced by derivative acyl in the structures of said compounds, therefore the compounds show good activity in antitumor vaccines.

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