Scheiflinger, Friedrih,Siekmann, Juergen,Turecek, Peter
申请号：
AU2005322067
公开号：
AU2005322067B2
申请日:
2005.12.23
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present invention relates to a proteinaceous construc (also designatedas polymer-VWF-conjugate) comprising plasmatic and/or recombinant von Willebrandfactor (VWF), said VWF being bound to at least one physiologically acceptablepolymer molecule, as well as to a complex said proteinaceous construc and at leastone factor VIII (FVIII) protein. The physiologically acceptable polymer moleculecan be, for instance, polyethylene glycol (PEG) or polysialic acid (PSA). Furtherthe present invention relates to methods for prolonging the half-lifeof VWF or FVIII in the blood of a mammal having a bleeding disorder associated withfunctional defects of or deficiencies of at least one of FVIII or VWF.
