#$%^&*AU2012202877A120120607.pdf#####Abstract The present invention is directed to novel 1,3,8-tiaza-spiro[4.5]decan-4-one derivatives of general formula wherein all variables are as defined herein, useful in the 5 treatment of disorders and conditions mediated by the ORL-1 G-protein coupled receptor. More particularly, the compounds of the present invention are useful in the treatment of disorders and conditions such as anxiety, depression, substance abuse, neuropathic pain, acute pain, migraine, asthma, cough and for improved cognition.