1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1 receptor mediated disorders

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专利权人:

Inc.;Ortho-McNeil Pharmaceutical

发明人:

Reitz, Allen B.,Pan, Kevin,Jordan, Alfonzo

申请号：

AU2008229844

公开号：

AU2008229844B2

申请日:

2008.10.09

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

#$%^&*AU2008229844B220120531.pdf#####Abstract The present invention is directed to novel 1,3,8-tiaza-spiro[4.5]decan-4-one derivatives of general formula wherein all variables are as defined herein, useful in the 5 treatment of disorders and conditions mediated by the ORL- 1 G-protein coupled receptor. More particularly, the compounds of the present invention are useful in the treatment of disorders and conditions such as anxiety, depression, substance abuse, neuropathic pain, acute pain, migraine, asthma, cough and for improved cognition.

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