The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I: where R1, R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ)activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.本發明係有關新穎之吲哚羧醯胺衍生物。明確言之，本發明係有關一種式I化合物：其中R1、R2、R3、U與V如下文中定義，與其醫藥上可接受之鹽。本發明化合物為IKK2之抑制劑，適用於治療與IKK2(亦稱為IKKβ)活性不當有關之病變，如：類風濕關節炎、氣喘與COPD(慢性阻塞性肺病)。因此，本發明進一步有關包含本發明化合物之醫藥組合物。本發明進一步亦有關使用本發明化合物或包含本發明化合物之醫藥組合物於抑制IKK2活性及治療與其相關病變上之用途。
