ALLEN, Shelley,ANDREWS, Steven S.,CONDROSKI, Kevin Ronald,HAAS, Julia,HUANG, Lily,JIANG, Yutong,KERCHER, Timothy,SEO, Jeongbeob
申请号：
ES10732606
公开号：
ES2655899T3
申请日:
2010.07.09
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound having the general formula I ** Formula ** or a salt thereof, wherein: R1 is H or (C1-6 alkyl)； R2 is H, (C1-6) alkyl, -fluoroalkyl (C1-6), -difluoroalkyl (C1-6), -trifluoroalkyl (C1-6), -chloroalkyl (C1-6), - chlorofluoroalkyl (C2-6) , -difluorochloroalkyl (C2-6), -chlorohydroxyalkyl (C2-6), -hydroxyalkyl (C1-6), - dihydroxyalkyl (C2-6), - (C1-6 alkyl) CN, - (C1-6 alkyl) SO2NH2 , - (C1-6 alkyl) NHSO2 (C1-3 alkyl), - (C1-6 alkyl) NH2, - (C1-6 alkyl) NH (C1-4 alkyl), - (C1-6 alkyl) N (alkyl C1-4) 2, - (C1-6 alkyl) NHC (>； = O) O (C1-4 alkyl), - (C1-6 alkyl) hetCyc1, - (C1-6 alkyl) hetAr1, hetAr2, hetCyc2, - O (C1-6 alkyl) which is optionally substituted with halogen, OH or C1-4 alkoxy, -O (C3-6 cycloalkyl), Cyc1, - (C1-6 alkyl) (C3-6 cycloalkyl), - ( C1-6 alkyl) (C1-4 alkoxy), - (C1-6 hydroxyalkyl) (C1-4 alkoxy), a bridged 7-membered cycloalkyl ring, optionally substituted with hydroxy (C1-6) alkyl, or a 7-heterocyclic ring -8 bridged members that have 1-2 nitrogen atoms in the ring； or NR1R2 forms a 4-6 membered azacyclic ring optionally substituted with one or more substituents independently selected from (C1-6) alkyl, OH, CO2H, (C1-3 alkyl) CO2H, -O (C1-6 alkyl) and hydroxyalkyl (C1-6)； hetCyc1 is a 5-6 membered heterocyclic ring having 1-2 ring heteroatoms independently selected from N and O, wherein hetCyc1 is optionally substituted with oxo, OH, halogen or (C1-6) alkyl； hetCyc2 is a 6-membered carbon-linked heterocyclic ring having 1-2 ring heteroatoms independently selected from N and O, wherein hetCyc2 is optionally substituted with F, SO2NH2, SO2 (C1-3 alkyl) or halogen； hetAr1 is a 5-membered heteroaryl ring having 1-2 ring heteroatoms independently selected from N and O and optionally substituted with (C1-4) alkyl； 30 hetAr2 is a 5-6 membered heteroaryl ring having 1-2 ring nitrogen atoms and optionally substituted with one or more substituents independently selected from (C1-4) alkyl, C3-6 cycloalkyl, halogen and OH ； Cyc1 is a 3-6 membered c
