5--2- - Cyclic amino substituted 5-arylfuran-2-carboxamide preparation method thereof and pharmaceutical composition for use in preventing or treating Urotensin- receptor activity related diseases containing the same as an active ingredient
LIM, CHAE JO,임채조,YI, KYU YANG,이규양,LEE, BYUNG HO,이병호,OH, KWANG SEOK,오광석,LEE, JEONG HYUN,이정현,SEO, HO WON,서호원,CHOI, JUN YOUNG,최준영
申请号：
KR1020170051767
公开号：
KR1018977970000B1
申请日:
2017.04.21
申请国别(地区):
KR
年份:
2018
代理人:
摘要：
The present invention relates to a 5-arylfuran-2-carboxamide derivative substituted with a cyclic amine group, a production method thereof, and a pharmaceutical composition for preventing or treating diseases associated with urotensin-II receptor activation containing same as an active ingredient. According to the present invention, the 5-arylfuran-2-carboxamide derivative substituted with the cyclic amine group acts as an antagonist to urotensin-II receptors, and thus can be useful for preventing or treating diseases associated with urotensin-II receptor activation such as congestive heart failure, ischemic heart disease, cardiac infarction, cardiac hypertrophy, myofibrosis cordis, coronary heart disease, arteriosclerosis, hypertension, asthma, renal failure, diabetes, vascular inflammation, neurodegenerative disease, stroke, pain, depression, psychosis, and cancer.본 발명은 사이클릭아민기가 치환된 5-아릴퓨란-2-카복시아마이드 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 유로텐신-Ⅱ 수용체 활성 관련 질환의 예방 또는 치료용 약학적 조성물에 관한 것이다. 본 발명에 따른 사이클릭아민기가 치환된 5-아릴퓨란-2-카복시아마이드 유도체는 유로텐신-Ⅱ 수용체에 대한 길항제로 작용함으로써 울혈성 심부전, 심장 허혈, 심근경색, 심장 비대증, 심장 섬유증, 관상동맥 질환, 동맥경화증, 고혈압, 천식, 신부전, 당뇨병, 혈관염증, 신경퇴행성 질환, 뇌졸중, 통증, 우울증, 정신병, 암 등과 같은 유로텐신-Ⅱ 수용체 활성 관련 질환을 예방 또는 치료하는데 유용하게 사용할 수 있다.
