Henrik Sune Andersen;John Paul Kilburn;Gita Camilla Tejlgaard Kampen
发明人:
John Paul Kilburn,Henrik Sune Andersen,Gita Camilla Tejlgaard Kampen
申请号：
US12529956
公开号：
US08153798B2
申请日:
2007.03.09
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The use of substituted amides of structure (I) for modulating the activity of 11 β-hydroxysteroid dehydrogenase type 1 (11 βHSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a novel class of substituted amides, their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds are modulators and more specifically inhibitors of the activity of 11 βHSD1 and may be useful in the treatment, prevention and/or prophylaxis of a range of medical disorders where a decreased intracellular concentration of active glucocorticoid is desirable.
