CAMACHO GOMEZ, JUAN ALBERTO,CASTRO-PALOMINO LARIA, JULIO CÉSAR
申请号：
ES11719879
公开号：
ES2534227T3
申请日:
2011.03.29
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula (I): ** Formula ** in which - R1 represents a five-membered heteroaryl ring selected from pyrazole, thiazole or triazole rings optionally substituted with one or two halogen atoms or with one or two groups methyl or trifluoromethyl - R2 represents a hydrogen atom - R3 represents a bromine atom, a chlorine atom or a cyano group - R4 independently represents: a) a five-membered heteroaryl group optionally substituted with one or more halogen atoms or with one or more C1-C8 alkyl, cycloalkyl, C1-C8 alkoxy, C1-C8 alkylthio, amino, mono- or di-C1-C8 alkylamino groups, b) a -N (R5) (R6) group in which R5 and R6 independently represent: - a hydrogen atom - an alkyl or cycloalkyl group of 3 to 6 carbon atoms, linear or branched, optionally substituted with one or more halogen atoms or with one or more cycloalkyl, hydroxy, C1-C8 alkoxy groups, amino, mono or C1-C8 dialkylamino - or R5 and R6 form together with the nitrogen atom to which a saturated 4- to 6-membered heterocyclic group is attached into which an additional heteroatom can be inserted, which is optionally substituted with one or more halogen atoms or with one or more C1-C8 alkyl groups, hydroxy, C1-C8 alkoxy, amino, mono- or C1-C8 dialkylamino, or c) a -OR7 or -SR7 group, in which R7 independently represents: - a C1-C8 alkyl or cycloalkyl group, linear or branched, optionally substituted with one or more halogen atoms or with one or more C1-C8 alkyl, C1-C8 alkoxy, amino, mono- or di-C1-C8 alkylamino groups - a phenyl ring optionally substituted with one or more halogen atoms or a salt pharmaceutically acceptable thereof.Un compuesto de fórmula (I):**Fórmula** en el que - R1 representa un anillo de heteroarilo de cinco miembros seleccionado de anillos de pirazol, tiazol o triazol opcionalmente sustituidos con uno o dos átomos de halógeno o con uno o dos grupos metilo o trifluorometilo - R2 representa un átomo de hidrógeno - R3 representa un átomo de bromo, un átomo de cloro o un grupo ciano -
