University of Louisville Research Foundation; Inc.
发明人:
Charles S. Hubscher,Susan J. Harkema,April N. Herrity,Yangsheng Chen,Claudia Angeli
申请号：
US16840353
公开号：
US20200316378A1
申请日:
2020.04.04
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to methods for improvement in lower urinary tract function in an individual with neurogenic urological dysfunction through epidural stimulation of the spinal cord. In certain embodiments, the methods comprise applying a pattern of epidural electrical stimulation to the spinal cord of an individual with impaired lower urinary tract under stimulation parameters sufficient to improve the storage of fluid in the bladder, sensations of fullness and/or emptying, detrusor over-activity, high detrusor pressure, voiding the bladder, transitioning from a storage state to a voiding state, and decreasing detrusor-external urethral sphincter dyssynergia. In certain embodiments, additional patterns of epidural electrical stimulation may be applied simultaneously, such as to maintain a normotensive cardiovascular state of the individual.
