A treatment process of radiological images is provided. The process comprises obtaining at least one set of images. For each set, the process comprises: segmenting an at least one first image to obtain an at least one first segmented image and to detect a plurality of arteries of the region of interest and an at least one second image to obtain an at least one second segmented image and to detect and isolate the tool defining in the at least one first segmented image a plurality of lines, wherein each line defines an artery determining, from the second segmented image and the defined lines, an artery of interest corresponding to the artery in which a tool has been inserted and applying a quantitative analysis algorithm of coronary lesions to the artery of interest to detect lesion of the artery of interest.