Problem to be solved: to provide an inhibitor of apoptosis and a Bcl-2 production promoter containing an extract of ginseng produced by heat treatment.\"Cosmetics, medicinal products, medicines and foods characterized by containing extracts of ginseng that has been processed by heat treatment. The extract of the heat treated ginseng of the present invention can be applied to a variety of diseases involved in increased apoptosis or increased Bcl-2 production because of the excellent Bcl-2 production promoting effect.Also, the inhibitor of apoptosis and the Bcl-2 production promoter of the present invention have no side effect because of the fact that the extract of the plant which the action is relaxed is effective ingredient, and the safety is high.No selection【課題】加熱処理をしたオタネニンジンの抽出物を含有するアポトーシス抑制剤及びBcl-2産生促進剤を提供する。【解決手段】加熱処理をしたオタネニンジンの抽出物を含有することを特徴とする化粧品、医薬部外品、医薬品及び食品。本発明の加熱処理をしたオタネニンジンの抽出物は優れたBcl-2産生促進効果を示すため、皮膚、毛髪等に生じるアポトーシスの亢進又はBcl-2の低下が関与する様々な疾患に対して応用できる。又、本発明のアポトーシス抑制剤及びBcl-2産生促進剤は、作用が緩和な植物の抽出物を有効成分とすることから、副作用がなく、安全性が高い。【選択図】なし