PROBLEM TO BE SOLVED: To provide a self-adhesive composition, and a percutaneous absorption-type preparation containing a rubber-based self-adhesive, having an excellent control ability of bleeding, and controlling an increase in crystal deposition of a medicament with time.SOLUTION: The self-adhesive composition used for the percutaneous absorption-type preparation includes: the medicament a medicament solubilizer for improving the solubility of the medicament the rubber-based self-adhesive polyvinylpyrrolidone and a higher fatty acid. The polyvinylpyrrolidone is contained in an amount effective for inhibiting volatilization of the medicament solubilizer. The higher fatty acid preferably contains isostearic acid. The medicament solubilizer preferably contains N-methyl-2-pyrrolidone.COPYRIGHT: (C)2010,JPO&INPIT【課題】ゴム系粘着剤を含有し、ブリーディングの抑制能に優れ且つ薬物の結晶析出の経時的な増加を抑制できる粘着性組成物及び経皮吸収型製剤を提供すること。【解決手段】経皮吸収型製剤に用いられる粘着性組成物は、薬物と、この薬物の溶解性を向上する薬物溶解剤と、ゴム系粘着剤と、ポリビニルピロリドンと、高級脂肪酸と、を含有する。ポリビニルピロリドンは、薬物溶解剤の揮発抑制有効量で含有され、高級脂肪酸は、イソステアリン酸を含むことが好ましい。また、薬物溶解剤は、N-メチル-2-ピロリドンを含むことが好ましい。【選択図】図1
