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DIPEPTIDE-BASED PRODRUG LINKERS FOR AROMATIC AMINE-CONTAINING DRUGS
专利权人:
Harald Rau;Dirk Vetter
发明人:
Dirk Vetter,Harald Rau
申请号:
US13574157
公开号:
US20130030359A1
申请日:
2011.01.21
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof, comprising a drug linker conjugate D-L, wherein D being a biologically active moiety containing an aromatic amine group is conjugated to one or more polymeric carriers via dipeptide-containing linkers. Such carrier-linked prodrugs achieve drug releases with therapeutically useful half-lives. The invention also relates to pharmaceutical compositions comprising said prodrugs and their use as medicaments.
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