THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY NAVAL MEDICAL RESEARCH CENTER; CODE 00L
发明人:
SAVARINO, STEPHEN
申请号：
CA2609173
公开号：
CA2609173C
申请日:
2006.05.23
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The invention relates to a method of producing a pharmaceutical compositionthatincludes anti-class 5 Escherichia coli immunoglobulin from domesticatedanimals, and whichis useful as a passive immunoprophylactic against class 5 enterotoxigenicEscherichia coli.The immunogen used to induce anti-class 5 E. coli immunity in the domesticatedanimalsincludes one or more constructs including stabilized enterotoxigenicEscherichia coli fimbrialadhesin or an adhesin domain of CfaE, CsbD or CotD. The immunoprophylactic ismade bycollecting anti-adhesin immunoglobulin in the colostrum or milk of vaccinateddomesticatedanimals, such as cows.
