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Mutant CTLA4 gene-transferred T cell and anticancer immunotherapeutic composition containing the same
专利权人:
ナショナル キャンサー センター
发明人:
チョイ、キュンホ,シン、ジェフン,リー、サン‐ジン
申请号:
JP2014538714
公开号:
JP6074435B2
申请日:
2012.10.26
申请国别(地区):
JP
年份:
2017
代理人:
摘要:
A transformed T-cell for T-cell therapy, and a composition including the same for anticancer immunotherapy. More particularly, the transformed T-cell is characterized by the transfection of a gene for coding a chimera protein. The T-cell, to which the gene for coding the chimera protein is transected, may improve the therapeutic effects induced by immune tolerance of cancer cells, and furthermore maximize anti-cancer effects by activating signal transduction to induce the activation of T-cells. Also, the disclosure allows treatments that minimize side effects such as the development of autoimmune diseases due to systematic T-cell activation.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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