Cobb, Ron;Ni, Yawei;Ology Bioservices, Inc.;Springer, Michael
发明人:
申请号：
EP16842675.7
公开号：
EP3341019A4
申请日:
2016.08.26
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
A dry powder norovirus vaccine is provided, which comprises at least two norovirus antigens representing different genogroups. The vaccine may be produced by formulation with a mixture of different antigens or combination of monovalent powders with each containing one antigen. The formulated vaccine is suitable for mucosal administration and soluble in aqueous solutions for parenteral administration. A method of immunization is also provided, which comprises at least one administration of the vaccine via mucosal and/or parental route. The immunization may have multiple administrations of the vaccine, i.e., one or more immunizations via a mucosal route followed by one or more immunizations via a parenteral route or vice versa, to maximize both mucosal and systemic immune responses and protection against norovirus infections.
