Michael Springer;Yawei Ni;Ron Cobb; Inc.;Ology Bioservices, Inc.;Ology Bioservices
发明人:
Cobb, Ron,Springer, Michael,Ni, Yawei
申请号：
AU2016317661
公开号：
AU2016317661A1
申请日:
2016.08.26
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
A dry powder norovirus vaccine is provided, which comprises at least two norovirus antigens representing different genogroups. The vaccine may be produced by formulation with a mixture of different antigens or combination of monovalent powders with each containing one antigen. The formulated vaccine is suitable for mucosal administration and soluble in aqueous solutions for parenteral administration. A method of immunization is also provided, which comprises at least one administration of the vaccine via mucosal and/or parental route. The immunization may have multiple administrations of the vaccine, i.e., one or more immunizations via a mucosal route followed by one or more immunizations via a parenteral route or vice versa, to maximize both mucosal and systemic immune responses and protection against norovirus infections.
