The present disclosure is directed to lysin-AMP polypeptide constructs, isolated lysin polypeptides, and pharmaceutical compositions comprising the isolated polypeptides and/or lysin-AMP polypeptide constructs. Methods of using the lysin-AMP polypeptide constructs, isolated lysin polypeptides and pharmaceutical compositions are also herein provided. In addition, isolated polynucleotides encoding the lysin-AMP polypeptide constructs and isolated lysin polypeptides are disclosed herein.La présente invention concerne des constructions polypeptidiques de lysine-AMP, des polypeptides de lysine isolés, et des compositions pharmaceutiques comprenant les polypeptides isolés et/ou les constructions polypeptidiques de lysine-AMP. L'invention concerne également des procédés d'utilisation des constructions polypeptidiques de lysine-AMP, des polypeptides de lysine isolés et des compositions pharmaceutiques. De plus, l'invention concerne des polynucléotides isolés codant pour les constructions polypeptidiques de lysine-AMP et les polypeptides de lysine isolés.
