UTILISATION DE MICROVÉSICULES (MV) DÉRIVÉES DE CELLULES-SOUCHES POUR LA PRÉPARATION D'UN MÉDICAMENT DESTINÉ LA RÉGÉNÉRATION ENDOTHÉLIALE/ÉPITHÉLIALE DE TISSUS OU D'ORGANES ENDOMMAGÉS OU LÉSÉS, ET PROCÉDÉS IN VITRO ET IN VIVO ASSOCIÉS
The invention relates to the use of microvesicles (MVs) derived from stem cells for preparing a medicament for the endo/epithelial regeneration of damaged tissues or organs and/or for inhibiting the apoptosis induced by cytostatic agents. The stem cell from which the microvesicles are obtained is preferably selected from the group consisting of endothelial progenitor cells (EPCs), mesenchimal stem cells (MSCs), renal progenitors CD133+, adult human liver stem cells (HLSC) and any combination thereof. The microvesicles may be used in both in vitro and in vivo applications, such as for example the regeneration of damaged tissues or organs and the treatment of renal injury and hepatic injury, particularly acute renal failure (ARF) and acute hepatic failure (AHF).
