СЕРБЬЕР Марк У. (US),БОСТИАН Кит А. (US),ЛОМОВСКАЯ Ольга (US),ГРИФФИТ Дэвид К. (US),ДАДЛИ Майкл Н. (US)
申请号：
RU2011118619/15
公开号：
RU2011118619A
申请日:
2011.05.10
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. A salt selected from the group consisting of levofloxacin xinafoate, levofloxacin oleate, levofloxacin palmitate, levofloxacin pamoate, levofloxacin estolate. ! 2. A dry powder containing particles having an average particle size with a volume average diameter of from about 2 μm to about 5 μm and a geometric standard deviation of particle size of less than or equal to about 2 μm, where the particles contain the salt according to claim 1. ! 3. A pharmaceutical composition comprising a suspension of particles containing a salt according to claim 1. ! 4. A method for treating a pulmonary infection, chronic obstructive pulmonary disease, cystic fibrosis or sinusitis, comprising administering a fluoroquinolone aerosol in combination with xinafoat, oleate, pamoat or estolate to a patient in need thereof. ! 5. The method according to claim 4, in which the fluoroquinolone is levofloxacin or ofloxacin. ! 6. The method of claim 4, wherein the fluoroquinolone is selected from the group consisting of ciprofloxacin, gatifloxacin, gemifloxacin, norfloxacin, moxifloxacin, Marbofloxacin, Orbifloxacin, sparfloxacin, tosufloxacin, trovafloxacin, pefloxacin, lomefloxacin, klinafloksatsina, prulifloksatsina, sarafloksatsina, and sitafloxacin pazufloksatsina . ! 7. A method of treating or preventing a microbial infection in a patient, comprising topically administering levofloxacin or ofloxacin to a patient to achieve an initial concentration of about 32 μg / ml of levofloxacin or ofloxacin in the foci of infection. ! 8. The method according to claim 7, in which an initial concentration of at least 128 μg / ml of levofloxacin or ofloxacin is achieved. ! 9. The method according to claim 7, in which an initial concentration of m is achieved1. Соль, выбранная из группы, состоящей из левофлоксацина ксинафоата, левофлоксацина олеата, левофлоксацина пальмитата, левофлоксацина памоата, левофлоксацина эстолата. ! 2. Сухой порошок, содержащий частицы, имеющие средний размер частиц с объемным
