Prevent or controlled the method for object disease of eye or disease complication, this method comprises makes vitreous body and/or aqueous humor contact with the compositions of the form fibrinolysin that comprises truncate (the catalyst structure domain TPCD that comprises fibrinolysin).TPCD includes, but are not limited to, little fibrinolysin (miniplasmin), fento lyase and their derivant and variant.Method of the present invention can be used to reduce Vitrea viscosity, make liquefaction of vitreous, induce rear vitreous body break away from, reduce eye hemorrhage, remove or reduce to the virose material of eyes, from ophthalmic remove or reduce allogenic material, increase to eye give the compositions of clothes diffusion, reduce extraretinal angiogenesis and above-mentioned any combination.This method can be used when not having vitrectomy or assisting as vitrectomy.
