A method for treatment of constipation and other ailments of the gastrointestinal system includes administering a pharmaceutically effective amount of a composition over a sufficient period of time that results in the production of nitric oxide in gastrointestinal cells and ultimately has beneficial results in treating constipation and other ailments of the gastrointestinal system. The composition comprises ginger or a ginger derivative, muira puama, and paullinia cupana that stimulates nitric oxide in gastrointestinal cells to increase NO and improve bowel functioning thereof.
