Almstead, Neil G.,Hwang, Peter Seongwoo,Moon, Young-Choon
申请号：
ES12185448
公开号：
ES2655338T3
申请日:
2007.09.24
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A process for preparing A-shaped crystals of 3- [5- (2-fluorophenyl) - [1,2,4] -oxadiazol-3-yl] -benzoic acid characterized by: an x-ray diffraction pattern of samples in powder comprising at least three peak positions (º2θ ± 0.2) when measured using Cu Kα radiation, selected from the group consisting of 4.96, 6.39, 10.10, 11.54, 12 , 62, 12.81, 13.92, 14.16, 14.55, 14.88, 15.07, 15.58, 16.27, 16.61, 18.74, 18.94, 19.28 , 19.94, 20.27, 20.74, 20.97, 21.22, 21.93, 22.58, 22.80, 23.00, 23.79, 24.14, 24.46, 25 , 44, 25.64, 26.07, 26.34, 26.74, 27.06, 27.79, 28.42, 29.09, 30.48； where the process comprises: (1) exposing a crystal in form B at a relative humidity of 79% at 60 ° C； or (2) grind a B-shaped crystal at room temperature or below room temperature； or (3) suspend a B-shaped crystal in methyl isobutyl ketone or in a 1: 1 mixture of dioxane and water； or (4) sublimate or heat a B-shaped crystal； where the B-shaped crystal of 3- [5- (2-fluorophenyl) - [1,2,4] -oxadiazol-3-yl] -benzoic acid has an X-ray diffraction pattern of representative powder samples as provided in figure 5.Un procedimiento para preparar cristales en forma A del ácido 3-[5-(2-fluorofenil)-[1,2,4]-oxadiazol-3-il]-benzoico caracterizado por: un patrón de difracción de rayos X de muestras en polvo que comprende al menos tres posiciones de pico (º2θ ± 0,2) cuando 5 se mide usando la radiación Kα de Cu, seleccionadas del grupo que consiste en 4,96, 6,39, 10,10, 11,54, 12,62, 12,81, 13,92, 14,16, 14,55, 14,88, 15,07, 15,58, 16,27, 16,61, 18,74, 18,94, 19,28, 19,94, 20,27, 20,74, 20,97, 21,22, 21,93, 22,58, 22,80, 23,00, 23,79, 24,14, 24,46, 25,44, 25,64, 26,07, 26,34, 26,74, 27,06, 27,79, 28,42, 29,09, 30,48； donde el procedimiento comprende: (1) exponer un cristal en forma B a una humedad relativa de 79% a 60 ºC； o (2) moler un cristal en forma B a temperatura ambiente o por debajo de la ambiente； o (3) poner en suspensión un cristal en forma B en metil isobutil cetona o en una mezcla 1:1 de dioxan
